Man I can't believe I just learned that Okami is available on Wii! The game came out at the end of 2006 on the PS2 and was one of the most visually unique games on that platform. Akin to a Legend of Zelda style action-adventure experience, you play the role of the Japanese sun god in an effort to return the kingdom to rights after a dark veil covers the land. From exciting boss fights to an enveloping story, Okami is a great adventure game.
IGN creams all over the Wii "port" in their review. This is a game I've eyed for a long time and would love to pick up. And it's a $40 title, woo woo!